Murchison a Clonally Transmissible Cancer The Tasmanian Devil Transcriptome Reveals Schwann Cell

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  • Elizabeth P. Murchison
چکیده

clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): May 18, 2011 www.sciencemag.org (this infomation is current as of The following resources related to this article are available online at http://www.sciencemag.org/content/327/5961/84.full.html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/content/suppl/2009/12/30/327.5961.84.DC2.html http://www.sciencemag.org/content/suppl/2009/12/29/327.5961.84.DC1.html can be found at: Supporting Online Material http://www.sciencemag.org/content/327/5961/84.full.html#related found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/content/327/5961/84.full.html#ref-list-1 , 6 of which can be accessed free: cites 25 articles This article http://www.sciencemag.org/content/327/5961/84.full.html#related-urls 3 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/medicine Medicine, Diseases subject collections: This article appears in the following

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The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer.

The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD...

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Schwann Cell Origins of a Clonally Transmissible The Tasmanian Devil Transcriptome Reveals

. clicking here colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others . here following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles (this information is current as of March 11, 2010 ): The following resources related to this article are available online at www....

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Genome Sequencing and Analysis of the Tasmanian Devil and Its Transmissible Cancer

The Tasmanian devil (Sarcophilus harrisii), the largest marsupial carnivore, is endangered due to a transmissible facial cancer spread by direct transfer of living cancer cells through biting. Here we describe the sequencing, assembly, and annotation of the Tasmanian devil genome and whole-genome sequences for two geographically distant subclones of the cancer. Genomic analysis suggests that th...

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A second transmissible cancer in Tasmanian devils.

Clonally transmissible cancers are somatic cell lineages that are spread between individuals via the transfer of living cancer cells. There are only three known naturally occurring transmissible cancers, and these affect dogs, soft-shell clams, and Tasmanian devils, respectively. The Tasmanian devil transmissible facial cancer was first observed in 1996, and is threatening its host species with...

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Transmissible cancer in Tasmanian devils: localized lineage replacement and host population response.

Tasmanian devil facial tumour disease (DFTD) is a clonally transmissible cancer threatening the Tasmanian devil (Sarcophilus harrisii) with extinction. Live cancer cells are the infectious agent, transmitted to new hosts when individuals bite each other. Over the 18 years since DFTD was first observed, distinct genetic and karyotypic sublineages have evolved. In this longitudinal study, we inve...

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تاریخ انتشار 2011